Post Cycle Therapy PCT An Overview

Consult with your physician if you are taking antidepressants, MAO inhibitors or other prescription drugs. This product should not be used by women or males under the age of 18. Below, we reviewed the clinical trial experience of AIs according to disease stage including metastatic and early stage disease as well as the role of AIs https://www.herrefrisoren.dk/2025/02/10/eca-understanding-its-role-in-health-and-fitness/ for chemoprevention. Important clinical trials of AIs are summarized in table 2 according to stage of the disease.

However, some bodybuilders tend to take it during the cycle as well as right after it to keep testosterone levels high by preventing the binding of estrogen. The recommended period for using Nolvadex is 4 weeks, although some protocols covering as few as 21 days exist. While AIs reduce circulating estrogen, SERMs can selectively block the effects of particular estrogen receptors. SERMs are generally not as effective at preventing or reversing all estrogenic side effects in the way that AIs can, but if SERMs are all you have access to, they will still provide benefits. The quality of drugs plays a significant role – compounds can be counterfeit and produced without proper drug production conditions. The drugs made this way may contain harmful by-products and bacterial infections, and the composition of different doses of the same drug may behave entirely differently.

Genius Estrogen Balance

• I’ve heard about some guys using this AI for PCT, though (perhaps they had no access to SERMs, which we should be using for PCT).
• ERα is the subtype of ER that is required for most of the known estrogenic responses 3.
• Approximately three quarter of breast cancer tumors express hormone receptors like ER and/or progesterone receptors (PR).
• Outside of breast cancer treatment, unlike Arimidex, Aromasin is rarely prescribed for any reason other than breast cancer treatment.
• Hi-Tech is also the only company selling a Cyclosomal version of Arimistane®, which dramatically increases the bioavailability of the compound.

Next up is Estrodex, a supplement designed for bodybuilders who need a post-cycle supplement to restore their hormones. DIM and grape seed extract are two of the most potent estrogen blockers available. Plus, Genius Estrogen Balance contains these compounds in the proper dosages.

Gynecomastia

What some guys don’t realize is that SOME water retention is not necessarily a bad thing. Joints, in particular, can benefit from some water, and if you want to add volume, then a bit of fluid is not always a negative. Vitamin B6 is an essential vitamin that you need for your health all the time, so why would we mention it specifically as it relates to prolactin? The active form of B6 (called pyridoxal 5′-phosphate or P-5-P) is known to decrease prolactin levels. If you’re interested in running a post-cycle therapy (PCT) cycle using Clomid, look at my in-depthClomid PCT guide.

Unlike most drugs, which are sold under multiple brand names, Aromasin is pretty much the only name you’ll find for Exemestane. Generics may exist in some countries, and these can often be cheaper than the name brand – however, you’d still need a prescription unless you can find generic Exemestane on the black market. Aromasin is a suicidal aromatase inhibitor, while Arimidex is a non-suicidal AI. It’s debatable whether the half-life is, in fact, the same in males.

DHT (Dihydrotestosterone) is a powerful androgenic hormone naturally made from testosterone in the body. So when Arimistane increases testosterone levels, we can expect DHT also to increase. However, DHT can also be created by DHEA, which is closely related to Arimistane. PCT-specific supplements contain Arimistane and other ingredients known to aid in the recovery and maintenance of post-steroid cycle gains. Like all supplements, not all of these PCT products are created equally. While some arimistane-based PCT supplements are of high quality, others can be very questionable, so it’s critical to research not only all the ingredients contained in the PCT supplement but also the company behind it.

Joint, bone, or muscle pain

Unlike steroidal inhibitors, inhibition by this type of AIs is reversible by competitive inhibition of androgens 4, 18. This particular subtype includes fadrozole, vorozole, rogletimide, letrozole and anastrozole. These agents were superseded by the newer generation of AIs with better oral bioavailability and fewer side effects 36. Currently, AIs that are now in clinical used and are approved by the US Food and Drug Administration (FDA) include anastrozole, letrozole, and exemestane.